Clonal Expansion of Environmental Triazole Resistant Aspergillus fumigatus in Iran

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dc.contributor.authorAhangarkani, Fatemeh
dc.contributor.authorBadali, Hamid
dc.contributor.authorAbbasi, Kiana
dc.contributor.authorNabili, Mojtaba
dc.contributor.authorKhodavaisy, Sadegh
dc.contributor.authorde Groot, Theun
dc.contributor.authorMeis, Jacques F.
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-06-21T18:10:21Z
dc.date.available2023-06-21T18:10:21Z
dc.date.issued2020-10-01
dc.description.abstractAzole-resistance in Aspergillus fumigatus is a worldwide medical concern complicating the management of aspergillosis (IA). Herein, we report the clonal spread of environmental triazole resistant A. fumigatus isolates in Iran. In this study, 63 A. fumigatus isolates were collected from 300 compost samples plated on Sabouraud dextrose agar supplemented with itraconazole (ITR) and voriconazole (VOR). Forty-four isolates had the TR34/L98H mutation and three isolates a TR46/Y121F/T289A resistance mechanism, while two isolates harbored a M172V substitution in cyp51A. Fourteen azole resistant isolates had no mutations in cyp51A. We found that 41 out of 44 A. fumigatus strains with the TR34/L98H mutation, isolated from compost in 13 different Iranian cities, shared the same allele across all nine examined microsatellite loci. Clonal expansion of triazole resistant A. fumigatus in this study emphasizes the importance of establishing antifungal resistance surveillance studies to monitor clinical Aspergillus isolates in Iran, as well as screening for azole resistance in environmental A. fumigatus isolates.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.description.sponsorshipNational Institutes for Medical Research Development; Mazandaran University of Medical Sciences, Sari, Iranen_US
dc.identifier.citationAhangarkani, F., Badali, H., Abbasi, K., Nabili, M., Khodavaisy, S., de Groot, T., & Meis, J. F. (2020). Clonal Expansion of Environmental Triazole Resistant Aspergillus fumigatus in Iran. Journal of Fungi, 6(4), 199. MDPI AG. Retrieved from http://dx.doi.org/10.3390/jof6040199en_US
dc.identifier.issn2309-608X
dc.identifier.otherhttps://doi.org/10.3390/jof6040199
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1917
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.rightsAttribution 3.0 United States*
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.subjectAspergillus fumigatusen_US
dc.subjectazole resistanceen_US
dc.subjectcomposten_US
dc.subjectTR34/L98Hen_US
dc.subjectTR46/Y121F/T289Aen_US
dc.subjectAspergillus fumigatus
dc.subjectazole resistance
dc.subjectcompost
dc.subjectTR34/L98H
dc.subjectTR46/Y121F/T289A
dc.titleClonal Expansion of Environmental Triazole Resistant Aspergillus fumigatus in Iranen_US
dc.typeArticleen_US

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