MNDB: An Integrated Database for Comprehensive Exploration of the N6-Methyladenosine Methylome




Ramachandran, Jithin Chandran

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The N6-methyladenosine (m6A) modification is recognized to have an important function incontrolling a variety of biological processes. This thesis introduces MNDB(Methyltranscriptome Network DataBase), a sophisticated database with a web interface that provides researchers with the ability to query N6-methyladenosine (m6A) modification sites by specific cell lines or tissue types, as well as differential methylation sites. We also constructed a novel pipeline that enabled us to compile millions of peaks from publicly available m6A-seq and MeRIP-seq data, covering numerous cell lines or tissues in various organisms. The MNDB web interface and genome browser provide an intuitive and visually appealing platform for exploring and analyzing the data, offering enhanced usability, functionality, and informativeness. Researchers can use this resource to obtain comprehensive insights into N6-methyladenosine (m6A) modification data, enabling them to make informed decisions and advance their research. The research demonstrates the potential of the advanced pipeline for studying the complex regulatory functions of N6-methyladenosine (m6A) modification and provides a valuable resource for the scientific community. The MNDB database is available for anyone to access and use.


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Electrical and Computer Engineering