Fundamental coordination chemistry of metalloporphyrins with sulfur-containing small molecules

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dc.contributor.advisorTonzetich, Zachary J.
dc.contributor.authorMeininger, Daniel J.
dc.contributor.committeeMemberKurtz, Donald M.
dc.contributor.committeeMemberArman, Hadi D.
dc.contributor.committeeMemberMusie, Ghezai T.
dc.date.accessioned2024-02-12T15:39:46Z
dc.date.available2016-06-10
dc.date.available2024-02-12T15:39:46Z
dc.date.issued2015
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractHydrogen Sulfide (H2S) has become a molecule of interest over the last few decades due to its observed biological activity. One area of interest is the ability of H2S to interact with metalloproteins, specifically hemeproteins, in both vertebrates and invertebrates. In similar fashion to carbon monoxide (CO) and nitric oxide (NO), H2S has been implicated as being an important signaling molecule. Unlike CO and NO, H2S has only begun to recently be studied and there is still much to learn about its basic modes of action in biological systems. This work concentrates on elucidating the fundamental chemistry regarding H2S at heme centers by way of synthetic models. A number of structural models of thiolate-bound iron porphyrinates have been synthesized and characterized and are reported herein. Using both ferric and ferrous systems, the reaction chemistry and stabilities of these biomimetic models are investigated. Along with iron, both gallium and manganese porphyrinates were investigated in hopes to provide further insight into H2S-heme chemistry.
dc.description.departmentChemistry
dc.format.extent237 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9781339309866
dc.identifier.urihttps://hdl.handle.net/20.500.12588/4476
dc.languageen
dc.subjectBiomimetic
dc.subjectHydrogen Sulfide
dc.subjectIron
dc.subjectPorphyrins
dc.subject.classificationChemistry
dc.subject.classificationInorganic chemistry
dc.subject.lcshHydrogen sulfide -- Synthesis
dc.subject.lcshHemoproteins
dc.subject.lcshBiomimetics
dc.titleFundamental coordination chemistry of metalloporphyrins with sulfur-containing small molecules
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentChemistry
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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